Blar i forfatter "Pichler, Martin"

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    • ALYREF, a novel factor involved in breast carcinogenesis, acts through transcriptional and post-transcriptional mechanisms selectively regulating the short NEAT1 isoform 

      Klec, Christiane; Knutsen, Erik; Schwarzenbacher, Daniela; Jonas, Katharina; Pasculli, Barbara; Heitzer, Ellen; Rinner, Beate; Krajina, Katarina; Prinz, Felix; Gottschalk, Benjamin; Ulz, Peter; Deutsch, Alexander; Prokesch, Andreas; Jahn, Stephan W.; Lellahi, Seyed Mohammad; Perander, Maria; Barbano, Raffaela; Graier, Wolfgang F.; Parrella, Paola; Calin, George Adrian; Pichler, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-01)
      The RNA-binding protein ALYREF (THOC4) is involved in transcriptional regulation and nuclear mRNA export, though its role and molecular mode of action in breast carcinogenesis are completely unknown. Here, we identifed high ALYREF expression as a factor for poor survival in breast cancer patients. ALYREF signifcantly infuenced cellular growth, apoptosis and mitochondrial energy metabolism in ...

    • Disclosing quantitative RT-PCR raw data during manuscript submission: a call for action 

      Untergasser, Andreas; Hellemans, Jan; Pfaffl, Michael W.; Ruijter, Jan M.; van den Hoff, Maurice J. B.; Dragomir, Mihnea P.; Adamoski, Douglas; Dias, Sandra Martha Gomes; Reis, Rui Manuel; Ferracin, Manuela; Dias-Neto, Emmanuel; Marsh, Ian; Kubista, Mikael; Fabbri, Muller; Goel, Ajay; Slabý, Ondřej; Knutsen, Erik; Chen, Baoqing; Negrini, Massimo; Mimori, Koshi; Pichler, Martin; Papatriantafyllou, Maria; Anfossi, Simone; Schmittgen, Thomas D.; Huggett, Jim; Bustin, Stephen; Vandesompele, Jo; Calin, George A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-14)
      Accuracy and transparency of scientific data are becoming more and more relevant with the increasing concern regarding the evaluation of data reproducibility in many research areas. This concern is also true for quantifying coding and noncoding RNAs, with the remarkable increase in publications reporting RNA profiling and sequencing studies. To address the problem, we propose the following ...

    • Metformin blocks MYC protein synthesis in colorectal cancer via mTOR-4EBP-eIF4E and MNK1-eIF4G-eIF4E signaling 

      Shen, Peng; Reineke, Lucas C.; Knutsen, Erik; Chen, Meng; Pichler, Martin; Ling, Hui; Calin, George A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-17)
      The antidiabetic drug metformin has been associated with reduced colorectal cancer (CRC) risk and improved prognosis of CRC patients. However, the detailed mechanisms underlying such beneficial effects remain unknown. In this study, we aimed to evaluate metformin activity in CRC models and unveil the underlying molecular mechanisms. We showed that metformin inhibits CRC cell proliferation by arresting ...